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To chime in with Lugia, here is a minimal FX setup: I have 4HP of multi fx processor (Disting MK4) which is fun, too.
For a minimal setup of pedal board FX I send things out via a headphone Cue and returing it via Mutable Ears. In my case it worked great with the BOSS DM-2W Delay, because I could also mix it back in the FX loop for well controllable feedback :)

PS.: Next up will be an FX Aid as dedicated processing module ;)