I try to keep things left to right, with a sort of normlization of proximity, so I can use short doepfer yellow wires as much as possible to avoid a drape of wires over everything. I'm building in 3 rows, so what's above and below also matter.
I also try and put a mult after signals that are valuable enough to spread around (if there's room).
Almost all of the racks I see here look like random modules in random positions, that they think are cool.
A wooden box full of interesting strings and pickups and knobs and wire is not a guitar.
How many racks laid out on Modular Grid ever got built?
A side note: See those two Doepfer Multicores, one by the clocks, and another starting the OXI Coral section?
You can use two ribbon cables on the backs to connect them, and they're passive and bidirectional.
Really helps to keep things neat, and the RJ45 connectors still can be used to extend to other cases.
Saves up to 14 long wires to distribute the clocks and triggers, and shorting RJ45 can turn a multicore pair into a distributed multiple.