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Oh, no doubt...but the key is to get a sequencer that properly emulates the TB-303's behavior, something like a Stepper Acid or similar. Beyond that, the sky's the limit as far as sound generation...and that factor is the big thing here. You can still have 303 patterns, but that 303 sequencer getting harnessed to some raw sonic power...THAT'S the point. Even if you do this in a DAW, it's still the "right thing to do" to use a 303-style sequencer to drive a very complex VSTi synth these days.

Ahhh, if only Aphex hadn't released the Most Expensive Acid Track Ever ("180db" on "Syro", which uses not one, not TWO, but THREE Korg PS3300s controlled by a 303), this would be SO much simpler...