Multiple sequencers are a kick and a half! My AE has several...three CV sequencers as well as a couple of trigger sequencer devices.
The big key to REALLY making multiple sequencers skip-n-jump is to dive into the world of clock modulators and Boolean logic. By having Boolean logic modules, you can take two gates and combine them in various ways to create different gate signals altogether. Pulse dividers/multipliers allow mathematical clock changes. Trigger sequencers such as Euclideans can add elements of stochastics to this, as can pulse skippers. And pulse delays can shift the overlaps between different gate signals, which then gives the Boolean gates even MORE to gnaw on. There's even a clock gen (from Evaton) that employs logic between two different clock generators to make the clocking more complex, too. And then you can ALSO use modules such as comparators and discriminators to "read" modulation signals and generate gate pulses from them as well. Lastly, pulse integrators (also known as "diode ORs") allow you to "mix" gates to create composite signals from those. And so on...LOTS of "so on", in fact...